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Effects of non-ablative vaginal erbium:YAG laser treatment for interstitial cystitis/bladder pain syndrome: a case series (UNICORN-2 study)

Okui, N., Okui, M. & Vizintin, Z.
Climacteric (2020). The journal of the International Menopause Society, 23(sup1), pp.S14–S17.

Abstract

Purpose: There are no established treatments for treating interstitial cystitis/bladder pain syndrome (IC/BPS). We conducted a study to verify the effectiveness of non-ablative vaginal erbium:YAG laser (VEL) treatment for patients with IC/BPS who were resistant to conventional treatments.

Methods: A total of 12 patients without improvement after several treatments before 2016 underwent VEL treatment once a month for 12 months as per their convenience. The numeric rating scale-11 (NRS-11), O'Leary-Sant interstitial cystitis symptom and problem indexes (ICSI and ICPI), functional bladder capacity, and daily urinary frequency were obtained.

Results: In total, nine patients responded to the treatment and three did not. The NRS-11 scores and ICSI and ICPI improved in all responders. The bladder capacity and urinary frequency also normalized. The residual effect lasted for 18 months from the first treatment without long-term side-effects.

Conclusions: VEL treatment is a safe and effective treatment in patients with IC/BPS.

Keywords: Non-ablative vaginal erbium:YAG laser; O'Leary–Sant symptom and problem indexes; daily urinary frequency; functional bladder capacity; interstitial cystitis/painful bladder syndrome; numeric rating scale.

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